In this unique stand-alone take on Pandemic, you are humanity's last hope against a threat from beyond this world. In Reign of Cthulhu, players work to shut down cults and ward off monsters while attempting to seal the gates. Travel between key locations in four cities central to the Cthulhu Mythos as you make use of your investigator's unique ability to stem the tide of evil. But be warned: Investigating the depths of chaos and madness will stretch your sanity to the limit. Encountering unspeakable monsters and using powerful Relic cards will lead you to the brink of insanity. Go over the edge and you'll have fewer actions and a weakened ability. Only by working together can you save the world from the unspeakable horror that lurks beyond the portals.